Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase

• Robert J. Kempton,
• Taylor A. Kidd-Kautz,
• Soizic Laurenceau and
• Stefan Paula

Beilstein J. Org. Chem. 2019, 15, 971–975, doi:10.3762/bjoc.15.94

• convey specificity for prostate cancer cells. Keywords: calcium ATPase inhibitors; Heck- and Suzuki-coupling reactions; hydroquinones; prostate cancer; tethered amino acid; Introduction Sarco/endoplasmic reticulum calcium ATPase (SERCA) is an integral protein that resides in the membrane of the

• with Boc groups present [23]. Conclusion Using Heck- and Suzuki-coupling reactions, we have developed a synthetic route that provides a BHQ template tethered to a leucine residue (14). Similar to its TG-based counterparts, 14 is an active SERCA inhibitor, which is a requirement for its potential use as